HCID 117724701, compound → HCID 136941920, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,4-dimethyl-3-(4-isopropoxy-3-methyl-phenyl)-5-methoxy-1H-pyrazole (described in Reference Preparation example 98) 7.4 g and 306 aqueous sulfuric acid solution 100 ml was stirred with heating under reflux for fifteen hours. Next, the following work-up treatments was carried out. The reaction mixture was cooled to 0° C., and the resulting precipitates were filtered and were washed with cool water to give some solids. Again, the filtrate were concentrated under reduced pressure to about a half volume and were cooled to 0° C., and the resulting precipitates were filtered and were washed with cool water to give some solids. These work-up treatments were carried out four times and the resulting all solids were dried under reduced pressure to give 4-(1,4-dimethyl-5-methoxy-1H-pyrazol-3-yl)-2-methyl-phenol 6.4 g.

Provenance & Evidence