反应详情

2-(4-Benzyloxy-phenyl)-ethanol (0.64 g, 2.80 mmol) obtained in Step B was dissolved in DCM (10 mL), and Dess-Martin periodinane (2.38 g, 5.60 mmol) was added thereto. The reactant was stirred at room temperature for 2 hours, diluted with DCM, and washed with Na2S2O3.5H2O aqueous solution. The remained organic solution was dried with MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.50 g, 79%).

1. washwashed with Na2S2O3.5H2O aqueous solution
2. dry with materialThe remained organic solution was dried with MgSO4
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by column chromatography (eluent, EtOAc/Hex=1/5)