Methanol → HCID 118290433, compound

Participants

Reaction Steps

At room temperature, the mixture of 5-{4-[2-Cyclopropyl-6-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-benzyloxy]-3-methyl-phenyl}-2,4-dimethyl-2H-pyrazole-3-carboxylic acid ethyl ester (Present compound 48) 1.4 g, tetrahydrofuran 40 ml, methanol 10 ml, water 10 ml and lithium hydroxide 0.2 g was stirred for twelve hours. The resulting mixture was concentrated under reduced pressure and was acidified with 10% hydrochloric acid solution and the mixture was extracted with ethyl acetate. The organic layer was washed with water and was dried over anhydrous magnesium sulfate, and was then concentrated under reduced pressure to give 5-{4-[2-Cyclopropyl-6-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-benzyloxy]-3-methyl-phenyl}-2,4-dimethyl-2H-pyrazole-3-carboxylic acid 1.3 g.

Provenance & Evidence