HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-(3-Bromo-5-chlorophenyl)-3-hydroxypropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 3-Bromo-5-chlorobenzaldehyde | HCID 17750952 | — |
| Product | 3-(3-Bromo-5-chlorophenyl)-3-hydroxypropanenitrile | HCID 66629520 | — |
Reaction Steps
Alkylation of 5-bromo-3-chlorobenzaldehyde with acetonitrile following the method used in Example 115 gave 3-(5-bromo-3-chlorophenyl)-3-hydroxypropanenitrile as a clear oil. Yield (3.21 g, 54%): 1H NMR (400 MHz, DMSO-d6) δ 7.62 (t, J=2.0 Hz, 1H), 7.58-7.57 (m, 1H), 7.49-4.48 (m, 1H), 6.18 (d, J=4.8 Hz, 1H), 4.93-4.90 (m, 1H), 2.93 (ABd, J=16.8, 5.2 Hz, 1H), 2.86 (ABd, J=17.2, 6.8 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09314467B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-0197a27b7c914c43a850c861dd8dbfb5 |
| Source note | uspto-grants-2016_04 |