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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62868Generated: October 25, 2026

2-Propanethiol → 2-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester

https://huagongshe.com/reaction/62868

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PropanethiolHCID 6364—
ReactantEthyl 2-chloropyrimidine-4-carboxylateHCID 22509306—
Product2-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl esterHCID 9011833168%

Reaction Steps

2-Chloropyrimidine-4-carboxylic acid ethyl ester (0.024 g, 0.13 mmol) obtained in Step A and 2-propanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (0.02 g, 68%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-bb76834c5a184a2880af0b5f4d64a1de
Source noteuspto-grants-2016_09