反应详情

9-(2-Fluoro-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid ethyl ester (30) (380 mg, 1.3 mmol) was dissolved in ethanol (3 mL) and then NaOH (520 nm) in water (5 mL) was added The reaction was heated at reflux for 2 h. The reaction was concentrated in vacuo and the residue diluted with water and washed with dichloromethane (2×50 mL). The aqueous layer was added drop wise to 2 N HCl (50 mL) and then extracted into dichloromethane (3×50 mL).

1. temperaturewas heated
2. temperatureat reflux for 2 h
3. concentrationThe reaction was concentrated in vacuo
4. additionthe residue diluted with water
5. washwashed with dichloromethane (2×50 mL)
6. additionThe aqueous layer was added drop wise to 2 N HCl (50 mL)
7. extractionextracted into dichloromethane (3×50 mL)