反应详情

1,1,3,3-Tetrakis(trifluoromethylsulfonyl)propane [4] (143.2 mg, 0.25 mmol) was added to an acetonitrile (0.25 ml) solution of 2,6-xylenol (34.1 mg, 0.28 mmol) at room temperature. After 3 hours of stirring, the reaction solution was concentrated under a reduced pressure. An obtained residue was purified by Kugelrohr distillation (180-200° C./3 mmHg) thereby obtaining 4-(2,2-bis(trifluoromethylsulfonyl)ethyl-2,6-dimethylphenol [1d] with a yield of 94% (96.9 mg, 0.234 mmol). Further, recrystallization was performed thereby obtaining a colorless crystal from hexane.

1. concentrationthe reaction solution was concentrated under a reduced pressure
2. distillationAn obtained residue was purified by Kugelrohr distillation (180-200° C./3 mmHg)