4-tert-Butylphenol → HCID 86712045, compound

HRID 628744Notes

Reaction equation

HRID 628744 reaction equation
FC(F)(F)S([CH:6](S(C(F)(F)F)(=O)=O)[CH2:7][CH:8]([S:16]([C:19]([F:22])([F:21])[F:20])(=[O:18])=[O:17])[S:9]([C:12]([F:15])([F:14])[F:13])(=[O:11])=[O:10])(=O)=O.[C:32]([C:36]1[CH:41]=C[C:39]([OH:42])=[CH:38][CH:37]=1)([CH3:35])([CH3:34])[CH3:33]>C(#N)C>[F:21][C:19]([F:20])([F:22])[S:16]([CH:8]([S:9]([C:12]([F:15])([F:14])[F:13])(=[O:11])=[O:10])[CH2:7][C:6]1[CH:41]=[C:36]([C:32]([CH3:35])([CH3:34])[CH3:33])[CH:37]=[CH:38][C:39]=1[OH:42])(=[O:17])=[O:18]

Participants

4

Reactant 2

HCID 73934-tert-ButylphenolHCID 204714221,1,3,3-Tetrakis(trifluoromethanesulfonyl)propane

Product 1

HCID 86712045HCID 86712045, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1,1,3,3-Tetrakis(trifluoromethylsulfonyl)propane [4] (148.8 mg, 0.264 mmol) was added to an acetonitrile (0.25 ml) solution of 4- t-butylphenol (43.6 mg, 0.29 mmol) at room temperature. After 1 hour of stirring, the reaction solution was concentrated under a reduced pressure. An obtained residue was purified by Kugelrohr distillation (190-210° C./5 mmHg) thereby obtaining 2-(2,2-bis(trifluoromethylsulfonyl)ethyl-4- t-butylphenol [1o] with an approximately quantitative yield (97.0 mg, 0.24 mmol).

Workup

  1. concentrationthe reaction solution was concentrated under a reduced pressure
  2. distillationAn obtained residue was purified by Kugelrohr distillation (190-210° C./5 mmHg)

Sources & evidence

ORD record
ord-950958b1f8a744e29019a26a058cc0d6
Source dataset
uspto-grants-2016_04
Patent number
US09314782B2

Reaction notes

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