2-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropane-carboxylic acid ethyl ester → Ethyl 2-(3,5-difluoro-4-hydroxyphenyl)cyclopropanecarboxylate

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Reaction Steps

2-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropane-carboxylic acid ethyl ester (0.65 g, 1.96 mmol) obtained in Step A was dissolved in EtOH (15 mL), and 10% Pd/C (65 mg) was added thereto. The mixture was stirred at room temperature under hydrogen atmosphere for 3 hours. The reactant was filtered by using celite and concentrated under reduced pressure to obtain the title compound (0.46 g, 97%).

Provenance & Evidence