3-Fluoro-p-anisaldehyde → Ethyl 3-(3-fluoro-4-methoxyphenyl)-2-methylprop-2-enoate

Participants

Reaction Conditions

Reaction Steps

After 3-fluoro-4-methoxy-benzaldehyde (0.50 g, 3.24 mmol) was dissolved in anhydrous THF (10 mL), carbethoxyethylidene triphenylphosphorane (1.75 g, 4.86 mmol) was added thereto at 0° C., and the mixture was stirred at room temperature for 3 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure and purified by column chromatography (eluent, EtOAc/Hex=1/2) to obtain the title compound (0.768 g, 99%).

Provenance & Evidence