HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole-5-carbonitrile → 3-(4-Chlorobutyl)-5-cyanoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole-5-carbonitrile | HCID 27513 | — |
| Reactant | 4-Chlorobutyryl chloride | HCID 78370 | — |
| Product | 3-(4-Chlorobutyl)-5-cyanoindole | HCID 9881123 | — |
| Product | 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile | HCID 10220528 | — |
Reaction Steps
According to U.S. Pat. No. 5,418,237 (hereinafter referred to as the '237 patent) & the Research Article ‘Drugs of the Future 2001, 26(3), 247’, 3-(4-chlorobutyl)-1H-indole-5-carbonitrile is prepared by reacting 5-cyanoindole with 4-chlorobutyryl chloride to give 3-(4-chlorobutyryl)-1H-indole-5-carbonitrile, which then reduced with diborane to produce the 3-(4-chlorobutyl)-1H-indole-5-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315456B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-b261078a5e434f6f8fb27c373f16a220 |
| Source note | uspto-grants-2016_04 |