HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 628809Generated: October 27, 2026
tert-Butyl methyl ether → Benzenamine, 2-bromo-6-fluoro-4-methyl-
https://huagongshe.com/reaction/628809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| Solvent | Water | HCID 962 | — |
| Product | Benzenamine, 2-bromo-6-fluoro-4-methyl- | HCID 26598247 | — |
Reaction Steps
6-fluoro-4-methylaniline 6 (15 kg) was added to a mixture of MTBE (92 L, 66.6 kg) calcium carbonate (12 kg) and water (135 kg), inerted and cooled to <5° C. Bromine (18.22 kg) was charged, keeping T<10° C. Age for 30 minutes at T<10° C. The batch was warmed to ˜18° C. and allowed to settle.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09315457B2 |
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| Source dataset | uspto-grants-2016_04 |
|---|
| ORD ID | ord-27b62c5f93e74f349340a31240891783 |
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| Source note | uspto-grants-2016_04 |
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