反应详情

Potassium botoxide (483 mg, 4.31 mmol) and MeOH (8 mL) were added to 2,6-dichloro-nicotinic acid (207 mg, 1.07 mmol), and the mixture was stirred using microwave at 60° C. for 1 hour. After the termination of the reaction, the reactant was filtered, and 1N HCl was added thereto at 0° C. to adjust the pH to 3. The solid was dried by N2 gas to obtain the title compound (106 mg, 52%).

1. customat 60° C.
2. customfor 1 hour
3. customAfter the termination of the reaction
4. filtrationthe reactant was filtered
5. addition1N HCl was added
6. customat 0° C.
7. dry with materialThe solid was dried by N2 gas