Triethylsilane → 3-(4-Benzyloxy-phenyl)-2,2-dimethyl-propionic acid ethyl ester

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Reaction Steps

3-(4-Benzyloxy-phenyl)-3-hydroxy-2,2-dimethyl-propionic acid ethyl ester (1.5 g, 4.57 mmol) obtained in Step B was dissolved in DCM (20 mL). Triethylsilane (0.81 mL, 5.03 mmol) was added thereto, and the reactant was cooled to 0˜5° C. After boron trifluoride diethylether (0.62 mL, 5.03 mmol) was added thereto at 0˜5° C., the mixture was heated to room temperature and stirred for 2 hours. Saturated sodium bicarbonate was added thereto, and the reactant was stirred. The separated organic layer was concentrated under reduced pressure, and the residue was purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (1.34 g, 94%).

Provenance & Evidence