HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroquinolin-6-ol → 3-(3-fluoro-4-(6-hydroxyquinolin-2-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Reactant | 4-Cyano-2-Fluorophenylboronic Acid | HCID 44755209 | — |
| Reactant | HCID 136078979 | HCID 136078979 | — |
| Product | 3-(3-fluoro-4-(6-hydroxyquinolin-2-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one | HCID 136078983 | — |
Reaction Steps
Followed procedure described for Compound 20 in Example 20 starting from 2-chloroquinolin-6-ol (Intermediate 2) and 4-cyano-2-fluorophenylboronic acid. 1H NMR (DMSO-d6, 300 MHz): δ 10.22 (1H, s), 8.27-8.33 (2H, m), 7.97 (1H, d, J=9 Hz), 7.77-7.82 (2H, m), 7.39 (1H, dd, J=3, 9 Hz), 7.21 (1H, d, J=3 Hz) ppm. MS (ESI): m/z 324.0 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315462B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-2787c26358a947d48766b6b4bf067c28 |
| Source note | uspto-grants-2016_04 |