反应详情

温度

-78 °C

4-Methoxy-2,3-dimethyl-benzaldehyde (2.0 g, 12.18 mmol) was dissolved in DCM (48 mL), and the solution was cooled to −78° C. 1M BBr3(24 mL, 24.13 mmol) was added slowly thereto, and the mixture was stirred at room temperature for 12 hours. After the termination of the reaction, the residue was diluted with water and extracted with DCM. The organic layer was dried with MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (187 mg, 10%).

1. customAfter the termination of the reaction
2. extractionextracted with DCM
3. dry with materialThe organic layer was dried with MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by column chromatography (eluent, EtOAc/Hex=1/5)