HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroquinolin-6-ol → 4-(6-Hydroxyquinolin-2-yl)-3-(trifluoromethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Reactant | Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)benzoate | HCID 66980121 | — |
| Product | 4-(6-Hydroxyquinolin-2-yl)-3-(trifluoromethyl)benzoic acid | HCID 56959063 | — |
Reaction Steps
Followed Scheme 3: starting with 2-chloroquinolin-6-ol and methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)benzoate (Intermediate 5). 1H NMR (DMSO-d6, 400 MHz): δ 10.21 (brs, 1H), 8.35-8.25 (m, 3H), 7.89 (d, J=9.2 Hz, 1H), 7.79 (d, J=8.0 Hz, 1H), 7.57 (d, J=8.4 Hz, 1H), 7.38 (dd, J=9.2, 2.8 Hz, 1H), 7.23 (d, J=2.4 Hz, 1H). MS (ESI): m/z 333.7 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315462B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3cdfaeeaebfe41f7b6c6a537c0e80f78 |
| Source note | uspto-grants-2016_04 |