反应详情

温度

150 °C

A suspension of 2,4-dichloro-6-methoxyquinoline (5.00 g, 22.0 mmol) in NH3 (g)/MeOH (saturated, 40 mL) was heated to 150° C. for 16 hours in a sealed tube. The solvent was removed in vacuo and the residue was diluted with MeOH (20 mL). The mixture was filtered off and the filtrate was concentrated to give the crude product, which was purified by column chromatography on silica gel (PE/EtOAc=2/1) to give 2-chloro-6-methoxyquinolin-4-amine (7.50 g, yield: 55%) as a yellow solid.

1. customThe solvent was removed in vacuo
2. additionthe residue was diluted with MeOH (20 mL)
3. filtrationThe mixture was filtered off
4. concentrationthe filtrate was concentrated
5. customto give the crude product, which
6. customwas purified by column chromatography on silica gel (PE/EtOAc=2/1)