HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 628921Generated: October 26, 2026
Hydrochloric Acid → 8-Fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one
https://huagongshe.com/reaction/628921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 3-chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide | HCID 66980071 | — |
| Product | 8-Fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one | HCID 10375048 | — |
Reaction Steps
3-Chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide (2.1 g) was mixed with anhydrous AlCl3 (7 g) and heated at 160° C. overnight. The resultant mixture was treated with 1N HCl and extracted with EtOAc. After isolation of the organic layer and removal of solvents under reduced pressure, the desired crude product (1.8 g) was collected as light brown solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09315462B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-6f03eb6fb6064ba79ecdc42a171ff5e8 |
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| Source note | uspto-grants-2016_04 |
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