HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 628924Generated: November 1, 2026
Phosphorus oxychloride → HCID 86689940, compound
https://huagongshe.com/reaction/628924
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178475467 | HCID 178475467 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86689940 | HCID 86689940 | — |
Reaction Steps
To a solution of 8-fluoro-2-hydroxyquinolin-6-yl acetate (550 mg) in DMF (6 mL) was added POCl3 (0.6 mL). Then, the mixture was heated at 80° C. over a couple of hours. After aqueous work-up, the desired product, 2-chloro-8-fluoroquinolin-6-yl acetate (380 mg) was obtained by flash silica column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09315462B2 |
|---|
| Source dataset | uspto-grants-2016_04 |
|---|
| ORD ID | ord-75f890ace3f14d37957ce262bced3fc3 |
|---|
| Source note | uspto-grants-2016_04 |
|---|
