Hydrochloric Acid → HCID 118037132, compound

Participants

Reaction Steps

Lithium hydroxide (0.32 mL of a 0.5N solution in H2O, 0.16 mmol) was added to a solution of the ester 13 (36 mg, 0.081 mmol) in THF (0.64 mL) at 23° C. After stirring for 24 h the reaction mixture was acidified with 1N HCl and extracted with EtOAc. The organic portion was washed with brine (2×), dried (Na2SO4), filtered and concentrated in vacuo to provide 27.6 mg (79%) of the free acid 14 (see Scheme 1).

Provenance & Evidence