4-Bromoaniline → 1-Methylethyl{(3S)-3-[(4-bromophenyl)amino]butanoyl}carbamate

1-Methylethyl (2E)-2-butenoylcarbamate (for a preparation see Intermediate 4) (9.38 g, 54.8 mmol) was stirred in toluene (281 ml) under nitrogen and (R-BINAP)ditriflatebis(acetonitrile)palladium(II) (for a preparation see Intermediate 5) (3.35 g, 3.01 mmol) added. The catalyst formed a gummy ball, the solution turned to an opaque yellow mixture and was stirred for 20 min. 4-Bromoaniline (14.14 g, 82 mmol) was added, the solution turned to a clear light brown and the gummy catalyst dissolved further. The mixture was stirred for 16 h. Similarly a second batch of 1-methylethyl (2E)-2-butenoylcarbamate (Intermediate 4, 8.51 g, 49.7 mmol) was stirred in toluene (255 ml) under nitrogen and (R-BINAP)ditriflatebis(acetonitrile)palladium(II) (3.04 g, 2.73 mmol) added. The catalyst formed a gummy ball, the solution turned to an opaque yellow mixture and was stirred for 20 min. 4-Bromoaniline (12.83 g, 74.6 mmol) was added, the solution turned to a clear light brown and the gummy catalyst dissolved further. The mixture was stirred for 16 h. The two reaction mixtures were combined and loaded on to a 1.5 kg Isco silica Redisep column. The column was eluted with DCM/methanol (0%→0.5%, 19 CV). The clean, product containing fractions were evaporated to a pale brown oil. The mixture was dried in a vaccum oven overnight at 40° C. to give 1-methylethyl {(3S)-3-[(4-bromophenyl)amino]butanoyl}carbamate as a white solid (24.2 g, 67% overall).

1. additionadded
2. customThe catalyst formed a gummy ball
3. dissolutiondissolved further
4. stirringThe mixture was stirred for 16 h
5. customThe catalyst formed a gummy ball
6. stirringwas stirred for 20 min
7. dissolutiondissolved further
8. stirringThe mixture was stirred for 16 h
9. customThe two reaction mixtures
10. washThe column was eluted with DCM/methanol (0%→0.5%, 19 CV)
11. additionThe clean, product containing fractions
12. customwere evaporated to a pale brown oil
13. customThe mixture was dried in a vaccum oven overnight at 40° C.

ORD record

ord-cc32ec783b3e42639a7540dbb927da58

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09315487B2