Sulfuric Acid → HCID 90118322, compound

HRID 62895Notes

Reaction equation

HRID 62895 reaction equation
Cl[CH2:2][C:3]1[C:12]2[C:7](=[C:8]([F:15])[C:9]([OH:14])=[C:10]([F:13])[CH:11]=2)[O:6][C:5](=[O:16])[CH:4]=1.S(=O)(=O)(O)[OH:18]>[OH-].[Na+]>[F:13][C:10]1[C:9]([OH:14])=[C:8]([F:15])[C:7]2[O:6][CH:2]=[C:3]([CH2:4][C:5]([OH:16])=[O:18])[C:12]=2[CH:11]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 18757590HCID 18757590, compound

Product 1

HCID 90118322HCID 90118322, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone (0.2 g, 0.81 mmol) obtained in Step A was dissolved in 1N NaOH aqueous solution (8 mL), and the mixture was stirred under reflux for 2 hours. The reactant was acidified by the addition of sulfuric acid, and then extracted with EtOAc. The organic layer was dried with MgSO4, and distilled under reduced pressure to obtain the title compound (0.16 g).

Workup

  1. temperatureunder reflux for 2 hours
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried with MgSO4
  4. distillationdistilled under reduced pressure

Sources & evidence

ORD record
ord-fa832b321433472cad9a2755ba052a0b
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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