反应详情

(5,7-Difluoro-6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (0.16 g, 0.66 mmol) obtained in Step C of Preparation Example 50 was dissolved in MeOH, and 10% Pd/C (30 mg) was added thereto. The mixture was stirred at room temperature under hydrogen atmosphere for 3 hours and then filtered. The filtrate was distilled under reduced pressure and then purified using EtOAc/Hex (1:4) solution by column chromatography to obtain the title compound (0.13 g, 81%).

1. filtrationfiltered
2. distillationThe filtrate was distilled under reduced pressure
3. custompurified