Phenyl isocyanate → HCID 67295490, compound

HRID 628978Notes

Reaction equation

HRID 628978 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:10]([O:12][C:13]([C:15]1[C:20]([O:21][CH2:22][CH3:23])=[C:19]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[N:18]=[C:17]([C:30]2[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][CH:31]=2)[N:16]=1)=[O:14])[CH3:11]>C1(C)C=CC=CC=1>[CH2:10]([O:12][C:13]([C:15]1[C:20]([O:21][CH2:22][CH3:23])=[C:19]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[N:18]=[C:17]([C:30]2[CH:31]=[CH:32][C:33]([NH:36][C:8]([NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:9])=[CH:34][CH:35]=2)[N:16]=1)=[O:14])[CH3:11]

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 67295455HCID 67295455, compound

Product 1

HCID 67295490HCID 67295490, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Phenyl isocyanate (0.22 ml, 1.5 eq.) was added to a stirred solution of 2-(4-Amino-phenyl)-5-ethoxy-6-morpholin-4-yl-pyrimidine-4-carboxylic acid ethyl ester (500 mg, 1 eq.) in toluene (25 ml) and the mixture was reacted for 4 h at 80° C. The reaction mixture was cooled, the solvent was removed in vacuo, and the residue was washed with EA and filtered to give a product (550 mg, 83%).

Workup

  1. customthe mixture was reacted for 4 h at 80° C
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed in vacuo
  4. washthe residue was washed with EA
  5. filtrationfiltered

Sources & evidence

ORD record
ord-00883a59c26c4129870fa8ee5a791bf8
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

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