Ethyl isocyanate → HCID 67297984, compound

HRID 628979Notes

Reaction equation

HRID 628979 reaction equation
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[CH2:6]([O:8][C:9]([C:11]1[C:16]([O:17][CH2:18][CH3:19])=[C:15]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[N:14]=[C:13]([C:26]2[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=2)[N:12]=1)=[O:10])[CH3:7]>C1(C)C=CC=CC=1>[CH2:6]([O:8][C:9]([C:11]1[C:16]([O:17][CH2:18][CH3:19])=[C:15]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[N:14]=[C:13]([C:26]2[CH:27]=[CH:28][C:29]([NH:32][C:4]([NH:3][CH2:1][CH3:2])=[O:5])=[CH:30][CH:31]=2)[N:12]=1)=[O:10])[CH3:7]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 67295455HCID 67295455, compound

Product 1

HCID 67297984HCID 67297984, compoundYield 25.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl isocyanate (0.012 ml, 1.4 eq.) was added to a stirred solution of 2-(4-amino-phenyl)-5-ethoxy-6-morpholin-4-yl-pyrimidine-4-carboxylic acid ethyl ester (40 mg, 1 eq.) in toluene (2 ml) and the mixture was reacted overnight at 80° C. The reaction mixture was extracted with EA, washed with brine. The crude was purified by chromatography to give a product (12 mg, 25.2%).

Workup

  1. customthe mixture was reacted overnight at 80° C
  2. extractionThe reaction mixture was extracted with EA
  3. washwashed with brine
  4. customThe crude was purified by chromatography

Sources & evidence

ORD record
ord-e2c8869218e047289bbce8209dc00eaf
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

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