1,2-Dichloroethane → HCID 67297756, compound

Participants

Reaction Steps

EDC (50 mg, 1.5 eq.), HOBT (40 mg, 1.5 eq.), Et2NH (0.0275 ml, 1.5 eq.) and Et3N (0.05 ml, 2.0 eq.) were added to a stirred solution of 5-ethoxy-6-morpholin-4-yl-2-[4-(3-phenyl-ureido)-phenyl]-pyrimidine-4-carboxylic acid (80 mg, 1 eq.) in dry DMF (2 ml) and the mixture reacted overnight at r.t. The mixture was quenched with H2O, extracted with EA, and washed with brine. The crude was purified by chromatography to give a product (43 mg, 48%).

Provenance & Evidence