反应详情

[2-(3-Fluoro-4-methoxy-phenyl)-cyclopropyl]-acetaldehyde (0.088 g, 0.42 mmol) obtained in Step C was dissolved in EtOH (2 mL). AgNO3(0.143 g, 0.84 mmol) dissolved in water (0.26 mL) and NaOH (0.067 g, 1.69 mmol) dissolved in water (0.26 mL) was added thereto in turn, and the mixture was stirred for 3 hours. After the termination of the reaction, the reactant was filtered by using celite to remove solid material, and 1N HCl aqueous solution was added to adjust the pH of the solution to 2. The organic layer obtained by the extraction with EtOAc was separated, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.075 g, 79%).

1. additionwas added
2. customAfter the termination of the reaction
3. filtrationthe reactant was filtered
4. customto remove solid material, and 1N HCl aqueous solution
5. additionwas added
6. customThe organic layer obtained by the extraction with EtOAc
7. customwas separated
8. dry with materialdried with MgSO4
9. concentrationconcentrated under reduced pressure