3-Nitrophenylboronic Acid → HCID 68274526, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(2-chloro-5-methoxy-pyrimidin-4-yl)-morpholine (0.2 g, 1.0 eq), 3-nitrophenyl boronic acid (0.17 g, 1.2 eq), (PPh3)4Pd (0.10 g, 0.1 eq) and 2 M Na2CO3 (1.3 ml, 3.0 eq) was heated at 80° C. and refluxed overnight. The solvent was removed in vacuo, and the residue was extracted with EA and water. The combined organic layers were washed with brine, dried and evaporated in vacuo. The crude was purified by chromatography to give a yellow solid (0.11 g, 39.97%).

Provenance & Evidence