Phenyl isocyanate → HCID 67295404, compound

HRID 628997Notes

Reaction equation

HRID 628997 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:10][O:11][C:12]1[C:13]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[N:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[N:16][CH:17]=1>O1CCOCC1>[CH3:10][O:11][C:12]1[C:13]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[N:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:8](=[O:9])[NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:20][CH:19]=2)=[N:16][CH:17]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 136352317HCID 136352317, compound

Product 1

HCID 67295404HCID 67295404, compoundYield 24.03%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

Phenyl isocyanate (0.03 ml, 2.0 eq) was added to a solution of 4-(5-methoxy-4-morpholin-4-yl-pyrimidin-2-yl)-phenol (0.05 g, 1.0 eq) in dioxane (6 ml) and heated at 80° C. for 20 hrs. The solvent was removed in vacuo, and the residue was extracted with EA and water. The combined organic layers were washed with brine, dried and evaporated in vacuo. The crude was purified by chromatography to give a white solid (0.07 g, 24.03%).

Workup

  1. customThe solvent was removed in vacuo
  2. extractionthe residue was extracted with EA and water
  3. washThe combined organic layers were washed with brine
  4. customdried
  5. customevaporated in vacuo
  6. customThe crude was purified by chromatography

Sources & evidence

ORD record
ord-8eaa4e4021ee4a969584b6f8dfa8a166
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

Loading…