HCID 67295426, compound → HCID 67297289, compound

HRID 629001Notes

Reaction equation

HRID 629001 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([N+:16]([O-])=O)[CH:10]=2)=[N:7][CH:8]=1>CO.CC(=O)OCC.[Pd]>[CH3:1][O:2][C:3]1[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[N:5][C:6]([C:9]2[CH:10]=[C:11]([NH2:16])[C:12]([NH2:15])=[CH:13][CH:14]=2)=[N:7][CH:8]=1

Participants

4

Reactant 1

HCID 67295426HCID 67295426, compound

Product 1

HCID 67297289HCID 67297289, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

A mixture of 4-(5-methoxy-4-morpholin-4-yl-pyrimidin-2-yl)-2-nitro-phenylamine (0.69 g, 1.0 eq.) and Pd/C (Cat.) in MeOH/EA (10 ml/10 ml) was prepared. The mixture was sharked and H2 gas was injected to the mixture for 4-6 hrs at room temperature. The mixture was filtered with Celite 454 and dried in vacuo to give a black sold (0.65 g, 99.9%) as a product.

Workup

  1. customwas prepared
  2. filtrationThe mixture was filtered with Celite 454
  3. customdried in vacuo
  4. customto give

Sources & evidence

ORD record
ord-c973d5b212fd43dc99d2025ef6fc01da
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

Loading…