Thionyl Chloride → HCID 90118321, compound

HRID 62902Notes

Reaction equation

HRID 62902 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([CH:16]2[CH2:18][CH:17]2[C:19](O)=[O:20])=[CH:11][C:10]=1[F:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:25]>>[CH2:1]([O:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([CH:16]2[CH2:18][CH:17]2[C:19]([Cl:25])=[O:20])=[CH:11][C:10]=1[F:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 901182402-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropanecarboxylic acid

Product 1

HCID 90118321HCID 90118321, compound

Procedure

After 2-(4-benzyloxy-3,5-difluoro-phenyl)-cyclopropanecarboxylic acid (75 mg, 0.246 mmol) was dissolved in anhydrous MC (5 ml), SOCl2 (0.58 g, 4.92 mmol) was added thereto, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure to obtain the title compound, which was used in the next step without a separate purification process.

Workup

  1. additionwas added
  2. customAfter the termination of the reaction
  3. concentrationthe reactant was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f21085ac22aa446089982359287b7962
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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