N,N-Dimethylaniline → HCID 86673510, compound

Participants

Reaction Steps

In ice bath, dimethyl-phenyl-amine (1.19 mL, 1.0 eq) was added dropwise to a slurry of 5-Methoxy-2-(4-nitro-phenyl)-3H-pyrimidin-4-one (2.3 g, 1.0 eq) in POCl3 (4.4 mL, 5.0 eq) and the mixture was refluxed overnight. Excess POCl3 was evaporated in vacuo and the residue was poured into ice-water. After formation of precipitates, the mixture was filtered and the residue was dried solid in vacuo. A product was obtained as a white solid (2.47 g, 61%).

Provenance & Evidence