反应详情

温度

0 °C

The NaOCH3 (7.8 g, 3 eq) was added to a stirred solution of 1-ethyl 3-methyl 2-methoxymalonate (11 g, 1.3 eq), 4-nitrobenzimidamide hydrochloride (9.6 g, 1 eq) and EtOH (240 ml) and the mixture was refluxed for 8 hrs. After 8 hrs, the solvent was evaporated and water (10˜15 ml) was added to the mixture then the mixture was cooled to 0° C. and carefully acidified with conc. HCl. After overnight cooling, it led to the formation of brown precipitates. The mixture was filtered and the precipitates was dried in vacuo to give a brown solid (65%) as a product.

1. temperaturethe mixture was refluxed for 8 hrs
2. customthe solvent was evaporated
3. additionwater (10˜15 ml) was added to the mixture
4. temperatureAfter overnight cooling
5. filtrationThe mixture was filtered
6. customthe precipitates was dried in vacuo