Dimethyl Sulfoxide → HCID 136338084, compound

Participants

Reaction Conditions

Reaction Steps

Process 5: Sodium hydrogen carbonate (1.19 g, 14.1 mmol) was added to dimethyl sulfoxide (15 mL) mixture of hydroxylamine hydrochloride (838 mg, 12.1 mmol) and stirred for 1 hour at 40° C. The reaction mixture was added dimethyl sulfoxide (15 mL) solution of 2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}benzonitrile (353 mg, 0.71 mmol) and stirred for 18 hours at 90° C. The reaction mixture was added water (80 mL) and ethyl acetate (20 mL) and stirred for 30 minutes. The precipitated solid was collected by filtration and washed with water and ethyl acetate. It was then dried in vacuo to give 2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N′-hydroxybenzimidamide (214 mg, 57%) as a white solid.

Provenance & Evidence