(Pyrimidin-5-yl)boronic acid → N-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(pyrimidin-5-yl)benzamide

関与物質

反応手順

The title compound was prepared in an analogous fashion to that described infashion to that described in Example 1 using N-(3-fluoro-4-(trifluoromethoxy)phenyl)-3-iodobenzamide (Stage 9.1) and pyrimidin-5-ylboronic acid to afford the title compound as a white solid. UPLC-MS (Condition 1) tR=2.63 min, m/z=378.0 [M+H]+, m/z=376.1 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 7.56-7.64 (m, 1H) 7.66 (dd, J=9.0, 1.2 Hz, 1H) 7.70-7.76 (m, 1H) 7.97-8.11 (m, 3H) 8.36 (s, 1H) 9.25 (s, 1H) 9.26 (s, 2H) 10.67 (s, 1H).

情報源と証拠