反应详情

After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropane carboxylic acid ethyl ester (1.15 g, 4.83 mmol) was dissolved in THF (6 mL), methyl alcohol (1 mL) and water (1 mL), an excess amount of sodium hydroxide was added, and then the mixture was stirred at room temperature for 4 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, and 1N HCl was added to adjust the pH of the solution to 2. The organic layer obtained by the extraction with ethyl acetate was separated, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain the title compound (0.985 g, 97%).

1. customAfter the termination of the reaction
2. concentrationthe reactant was concentrated under reduced pressure, and 1N HCl
3. additionwas added
4. customThe organic layer obtained by the extraction with ethyl acetate
5. customwas separated
6. dry with materialdried with anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure