6-Bromopyridine-2-carboxylic acid → HCID 89906671, compound

HRID 629117Notes

Reaction equation

HRID 629117 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.[F:11][C:12]([F:22])([F:21])[O:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>>[Br:1][C:2]1[N:7]=[C:6]([C:8]([NH:18][C:17]2[CH:19]=[CH:20][C:14]([O:13][C:12]([F:11])([F:21])[F:22])=[CH:15][CH:16]=2)=[O:10])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5939196-Bromopyridine-2-carboxylic acidHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 89906671HCID 89906671, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 59.1 using 6-bromopicolinic acid and 4-(trifluoromethoxy)aniline to afford the title compound as a white powder. UPLC-MS (Condition 2) tR=1.27 min, m/z=361.0/363.0 [M+H]+.

Workup

  1. customThe title compound was prepared in an analogous fashion to

Sources & evidence

ORD record
ord-181b8eb166ba42ef9beec928e6b0f5f1
Source dataset
uspto-grants-2016_04
Patent number
US09315489B2

Reaction notes

Loading…