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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 629136Generated: October 29, 2026

4-Hydroxybenzaldehyde → 4-Isobutoxybenzaldehyde

https://huagongshe.com/reaction/629136

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-HydroxybenzaldehydeHCID 126—
ReactantSodium IodideHCID 5238—
Reactant1-Bromo-2-methylpropaneHCID 6555—
Product4-IsobutoxybenzaldehydeHCID 249810100.6%

Reaction Steps

The compound was synthesized as in Example 24.1, using 4-hydroxybenzaldehyde (200 mg, 1.64 mmol) and isobutyl bromide (449 mg, 1.97 mmol) in place of 1-chloro-3,3-dimethylbutane (no sodium iodide was used) to give 4-isobutoxybenzaldehyde (294 mg, quant. crude) as a yellow oil that was used without further purification or characterization.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315495B2
Source datasetuspto-grants-2016_04
ORD IDord-e7477957f44c4f2ba7ccbb8b4cb40e2c
Source noteuspto-grants-2016_04