5-Bromothiophene-2-carbaldehyde → HCID 118230550, compound

HRID 629142Notes

Reaction equation

HRID 629142 reaction equation
Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:18])([F:17])[CH2:11][CH2:12][B-](F)(F)F>>[F:9][C:10]([F:18])([F:17])[CH2:11][CH2:12][C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 784285-Bromothiophene-2-carbaldehydeHCID 56972907HCID 56972907, compound

Product 1

HCID 118230550HCID 118230550, compoundYield 90%

Procedure

The compound was synthesized as in Example 3.1 using 5-bromothiophene-2-carbaldehyde (250 mg, 1.31 mmol) in place of 5-bromo-2-formylfuran and 3,3,3-trifluoropropyltrifluoroborate (440 mg, 2.16 mmol) in place of hexylboronic acid to give 5-(3,3,3-trifluoropropyl)thiophene-2-carbaldehyde (244 mg, 90%). Used without further characterization.

Sources & evidence

ORD record
ord-c0b0cf39401e4289b777b2538aa53632
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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