5-Bromothiophene-2-carbaldehyde → HCID 118228967, compound

HRID 629143Notes

Reaction equation

HRID 629143 reaction equation
Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1.[CH:9]1([CH2:15][CH2:16]B(O)O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH:9]1([CH2:15][CH2:16][C:2]2[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=2)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 784285-Bromothiophene-2-carbaldehydeHCID 44228204HCID 44228204, compound

Product 1

HCID 118228967HCID 118228967, compoundYield 58%

Procedure

The compound was synthesized as in Example 3.1 using 5-bromothiophene-2-carbaldehyde (250 mg, 1.31 mmol) in place of 5-bromo-2-formylfuran and 2-cyclohexylethylboronic acid (337 mg, 2.16 mmol) in place of hexylboronic acid to give 5-(2-cyclohexylethyl)thiophene-2-carbaldehyde (168 mg, 58%). Used without further characterization.

Sources & evidence

ORD record
ord-c88be4704a274e4fb98e00b9be48c920
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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