HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzyl-1,3-oxazolidin-2-one → 2-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzyl-1,3-oxazolidin-2-one | HCID 559668 | — |
| Reactant | 2-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid | HCID 90118225 | — |
| Product | 2-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid methyl ester | HCID 90118302 | 60% |
Reaction Steps
The mixture (85 mg) of 2-(4-benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid and 4-benzyloxazolidin-2-on obtained in Step A was reacted in the same manner as in Step B of Preparation Example 59 to obtain the title compound (54 mg, two-step yield 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-0fbf27ca1b824917bd2391ec9e746adc |
| Source note | uspto-grants-2016_09 |