Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → ethyl(2E)-3-(2-fluoro-4-methoxyphenyl)acrylate

Participants

Reaction Steps

2-Fluoro-4-methoxy-benzaldehyde (1.24 g, 3.56 mmol) and carbethoxy methylene triphenylphosphorane (2.0 g, 5.78 mmol) were dissolved in THF (10 mL), and the mixture was stirred at 65˜75° C. for 1 hour. After the termination of the reaction, the reactant was cooled, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/10) to obtain the title compound (0.6 g, 83%).

Provenance & Evidence