Methyl iodide → 1-Bromo-2-methoxy-3-nitrobenzene

Participants

Reaction Steps

2-Bromo-6-nitrophenol (5.0 g, 22.9 mmol) was dissolved in DMF (3 mL), potassium carbonate (4.75 g, 34.4 mmol) was added and the reaction was stirred for 30 minutes. Next iodomethane (2.15 mL, 34.4 mmol) was added and the reaction was stirred overnight. The crude reaction was filtered, diluted with ethyl acetate and washed with brine (twice) and water (twice). The organic layer was dried over sodium sulfate, filtered and concentrated to provide 1-bromo-2-methoxy-3-nitrobenzene (5.12 g, 96%). LC retention time 0.92 [J].

Provenance & Evidence