Ammonia → HCID 86702436, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-bromo-5-fluoro-3-methyl-indole (2.5 g), Cu (0.77 g), CuBr (1.57 g) and NH3 (30 ml of a 33% aqueous solution) was heated in an autoclave for 2 h at 170° C. The mixture was diluted with water and extracted with EtOAc. The organic phase was dried and the solvent removed to give 3-methyl-5-fluoro-7-amino-indole as an oil which was used without further purification. UPLC/MS found for C9H9FN2 as (M+H)+165.2

Provenance & Evidence