Ammonia → HCID 86702437, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-bromo-5-fluoro-indole (1 g), Cu (0.31 g), CuBr (0.64 g) and NH3 (30 ml of a 33% aqueous solution) was heated in an autoclave for 1.5 h at 155° C. The mixture was diluted with water and extracted with EtOAc. The organic phase was dried and the solvent removed to give 5-fluoro-7-amino-indole as an oil which was used without further purification. UPLC/MS found for C8H7FN2 as (M+H)+ 151.0.

Provenance & Evidence