反应详情

To a suspension of 4,6-dichloro-1-hydroxy-1H-furo[3,4-c]pyridin-3-one (9.37 g) stirring in water (100 ml) was added hydrazine sulfate (10.58 ml) and sodium acetate (13.56 g). The reaction mixture was heated at reflux and stirred for 2 h. The reaction mixture was cooled to RT, diluted with water (150 ml) and extracted with EtOAc (2×75 ml). The combined organic layers were washed with saturated Na2CO3 solution and dried over Na2SO4. Evaporation to dryness gave the desired product as brown solid.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux
3. extractionextracted with EtOAc (2×75 ml)
4. washThe combined organic layers were washed with saturated Na2CO3 solution
5. dry with materialdried over Na2SO4
6. customEvaporation to dryness