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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62922Generated: October 25, 2026

Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoate → 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid ethyl ester

https://huagongshe.com/reaction/62922

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(4-hydroxyphenyl)-2-methylpropanoateHCID 20748401—
Reactant3-Chloromethyl-2-isopropylsulfanyl-pyridineHCID 53816681—
Product3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid ethyl esterHCID 9011820153.5%

Reaction Steps

3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.063 g, 0.31 mmol) obtained in Step C of Preparation Example 1 and 3-(4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (0.065 g, 0.31 mmol) obtained in Step B of Preparation Example 3 were reacted in the same manner as in Step A of Example 1 to obtain the title compound (0.062 g, 53%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-5bf84665a5bb4ea2846f25921390c4cc
Source noteuspto-grants-2016_09