HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-(2-(trimethylsilyl)ethynyl)pyridine → (3aRS,6aSR)-1-Methyl-3-(5-trimethylsilanylethynyl-pyridin-2-yl)-hexahydro-cyclopenta-imidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-(2-(trimethylsilyl)ethynyl)pyridine | HCID 12983092 | — |
| Reactant | (3aRS,6aSR)-1-Methyl-hexahydro-cyclopentaimidazol-2-one | HCID 59655249 | — |
| Product | (3aRS,6aSR)-1-Methyl-3-(5-trimethylsilanylethynyl-pyridin-2-yl)-hexahydro-cyclopenta-imidazol-2-one | HCID 67436711 | — |
Reaction Steps
The title compound, an off-white solid, MS: m/e=314.1 (M+H+), was prepared in accordance with the general method of example 106, step 4 starting from 2-bromo-5-((trimethylsilyl)ethynyl)-pyridine (Example 37, step 1) and (3aRS,6aSR)-1-methylhexahydrocyclopenta[d]imidazol-2(1H)-one (Example 106, step 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315498B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-257d7397e1b94a6bb4b812759ba8a84f |
| Source note | uspto-grants-2016_04 |