HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-3-iodobenzene → (3aSR,6aRS)-1-[5-(3-Fluoro-phenylethynyl)-pyridin-2-yl]-3-methyl-hexahydro-cyclopenta-imidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-3-iodobenzene | HCID 70725 | — |
| Reactant | (3aRS,6aSR)-1-Methyl-3-(5-trimethylsilanylethynyl-pyridin-2-yl)-hexahydro-cyclopenta-imidazol-2-one | HCID 67436711 | — |
| Product | (3aSR,6aRS)-1-[5-(3-Fluoro-phenylethynyl)-pyridin-2-yl]-3-methyl-hexahydro-cyclopenta-imidazol-2-one | HCID 53494161 | — |
Reaction Steps
The title compound, a light yellow oil, MS: m/e=336.2 (M+H+), was prepared in accordance with the general method of Example 37, step 3 starting from (3aRS,6aSR)-1-methyl-3-(5-trimethylsilanylethynyl-pyridin-2-yl)-hexahydro-cyclopenta-imidazol-2-one (Example 109, step 1) and 1-fluoro-3-iodobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315498B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-f6a89f7f04074793834ff8e11ca4f034 |
| Source note | uspto-grants-2016_04 |